研究業績（２０００年以降）

1. Liu, X., Takahashi, H., Harada, Y., Ogawara, T., Ogimura, Y., Mizushina, Y., Saneyoshi, M. and Yamaguchi, T. (2007) 3'-Azido-2',3'-dideoxynucleoside 5'-triphosphates inhibit telomerase activity in vitro, and the corresponding nucleosides cause telomere shortening in human HL60 cells. Nucleic Acids Res., 35, in press.
2. Liu, X., Liu, J., Ogawara, T., Kurashina, Y., Yashi, R., Saneyoshi, M. and Yamaguchi, T. (2007) Influence of nucleoside analogue treatment on telomere length and TRF2 amount in human HL60 cells. Nucleic Acids Symp. Ser. (Oxf.), 253-254.
3. Liu, X., Inomata, M., Ogawara, T., Saneyoshi, M. and Yamaguchi, T. (2007) Telomere shortening in human HL60 cells by treatment with 3'-azido-2',3'-dideoxynucleosides and telomerase inhibition by their 5'-triphosphates. Nucleosides Nucleotide Nucleic Acids, 24, in press.
4. Yamaguchi, T., Saneyoshi, M., Takahashi, H., Hirokawa, S., Amano, R., Liu, X., Inomata, M. and Maruyama, T. (2006) Synthetic nucleosides and nucleotides. 43. Inhibition of vertebrate telomerases by carbocyclic oxetanocin g (C.OXT-G) triphosphate analogues and influence of C.OXT-G treatment on telomere length in human HL60 cells. Nucleosides Nucleotides Nucleic Acids, 25, 539-551.
5. Yamaguchi, T., Liu, X., Ogawara, T., Inomata, M. and Saneyoshi, M. (2006) Telomerase inhibition by 3'-azido-2', 3'-dideoxynucleoside 5'-triphosphates and telomere shortening in human cultured cells by the corresponding nucleosides. Nucleic Acids Symp. Ser. (Oxf.), 271-272.
6. Yamaguchi, T., Kazama, K., Takashima, J., Ogawara, T., Iyono, S., Inomata, M. and Saneyoshi, M. (2005) Influence of long-term treatment with cytosine arabinoside on telomere length in human HL60 cells. Nucleic Acids Symposium Ser., 49, 289-290.
7. Yamaguchi, T., Takahashi, H., Harada, Y., Yoshikawa, M., Iyono, S., Inomata, M., Maruyama, T. and Saneyoshi, M. (2004) Telomere shortening in human HL60 cells by treatment with deoxyguanosin analogs. Nucleic Acids Symposium Ser., 48, 187-188.
8. Yamaguchi, T., Takahashi, H., Jinmei, H., Takayama, Y. and Saneyoshi, M. (2003) Inhibition of vertebrate telomerases by the triphosphate derivatives of some biologically active nucleosides. Nucleosides Nucleotides Nucleic Acids, 22, 1575-1577.
9. Takahashi, H., Amano, R., Saneyoshi, M., Maruyama, T. and Yamaguchi, T. (2003) Inhibition of vertebrate telomerases by the triphosphate derivatives of carbocyclic oxetanocin analogs. Nucleic Acids Res. Suppl., 285-286.
10. Mizushina, Y., Xu, X., Asahara, H., Takeuchi, R., Oshige, M., Shimazaki, N., Takemura, M., Yamaguchi, T., Kuroda, K., Linn, S., Yoshida, H., Koiwai, O., Saneyoshi, M., Sugawara, F. and Sakaguchi, K. (2003) A sulphoquinovosyl diacylglycerol is a DNA polymerase e inhibitor. Biochem. J., 370, 299-305.
11. Mizushina, Y., Murakami, C., Yogi, K., Ueda, K., Ishidoh, T., Takemura, M., Perpelescu, M., Suzuki, M., Oshige, M., Yamaguchi, T., Saneyoshi, M., Yoshida, H. and Sakaguchi, K. (2003) Kohamaic acid A, a novel sesterterpenic acid, inhibits activities of DNA polymerases from deuterostomes. Biochim. Biophys. Acta, 1648, 55-61.
12. Mizushina, Y., Murakami, C., Takikawa, H., Kasai, N., Xu, X., Mori, K., Oshige, M., Yamaguchi, T., Saneyoshi, M., Shimazaki, N., Koiwai, O., Yoshida, H., Sugawara, F. and Sakaguchi, K. (2003) Molecular action mode of Hippospongic acid A, an inhibitor of gastrulation of starfish embryos. J. Biochem. (Tokyo), 133, 541-552.
13. Jinmei, H., Takahashi, H., Amano, R., Suzuki, K., Saneyoshi, M. and Yamaguchi, T. (2002) Telomerase-inhibitory effects of sugar-modified nucleotide analogs. Nucleic Acids Res. Supplement, 2, 221-222.
14. Yamaguchi, T., Yamada, R., Tomikawa, A., Shudo, K., Saito, M., Ishikawa, F. and Saneyoshi, M. (2001) Inhibition of human telomerase by L-enantiomers of natural 2'-deoxyribonucleoside 5'-triphosphates. Nucleosides Nucleotides Nucleic Acids, 20, 1243-1246.
15. Yamaguchi, T., Takayama, Y., Saito, M., Ishikawa, F. and Saneyoshi, M. (2001) Telomerase-inhibitory effects of the triphosphate derivatives of some biologically active nucleosides. Nucleic Acids Res. Supplement, 1, 211-212.
16. Mizushina, Y., Sugiyama, Y., Yoshida, H., Hanashima, S., Yamazaki, T., Kamisuki, S., Ohta, K., Takemura, M., Yamaguchi, T., Matsukage, A., Yoshida, S., Saneyoshi, M., Sugawara, F. and Sakagauchi, K. (2001) Galactosyldiacylglycerol, a mammalian DNA polymerase alpha-specific inhibitor from a sea alga, Petalonia bingbamiae. Biol. Pharm. Bull., 24, 982-987.
17. Yamaguchi, T., Yamada, R., Tomikawa, A., Shudo, K., Saito, M., Ishikawa, F. and Saneyoshi, M. (2000) Recognition of 2'-deoxy-L-ribonucleoside 5'-triphosphates by human telomerase. Biochem. Biophys. Res. Commun., 279, 475-481.
18. Yamaguchi, T., Kawarai, M., Takeshita, Y., Ishikawa, F. and Saneyoshi, M. (2000) Inhibition of human telomerase by nucleotide analogues bearing a hydrophobic group. Nucleic Acids Symp. Ser., 44, 175-176.
19. Mizushina, Y., Ueno, T., Oda, M., Yamaguchi, T., Saneyoshi, M. and Sakaguchi, K. (2000) The biochemical mode of inhibition of DNA polymerase beta by alpha-rubromycin. Biochim. Biophys. Acta, 1523, 172-181.
20. Mizushina, Y., Kamisuki, S., Mizuno, T., Takemura, M., Asahara, H., Linn, S., Yamaguchi, T., Matsukage, A., Hanaoka, F., Yoshida, S., Saneyoshi, M., Sugawara, F. and Sakaguchi, K. (2000) Dehydroaltenusin, a mammalian DNA polymerase alpha inhibitor. J. Biol. Chem., 275, 33957-33961.