教員一覧

教員詳細

彦野 弘一 (ひこの ひろかず)

彦野 弘一

役職:学科長・教授・博士(獣医学)

主な研究と活動

動物の健康を保ち、その生命を衛るために、動物における微生物の感染に対する免疫応答およびワクチンについて研究しています。動物保健衛生学研究室では、論文講読と卒業研究を通じて、動物感染症学についての専門的な知識とスキルを身につけ、動物病院や検査・研究機関などの幅広い動物関連職域において活躍できる人材の育成を目指しています。

キーワード 動物感染症、免疫応答、ワクチン
専門分野 獣医免疫学、獣医感染症学、獣医微生物学
主な研究対象

免疫応答、ウイルス、細菌、牛、豚、鶏

担当科目 動物病原微生物学、動物感染症学、公衆衛生学、動物病理学
研究室番号 16-16
免許・資格
  • 獣医師免許
卒業年月
  • 1992年 3月 東京農工大学 農学部 獣医学科
学歴・経歴
  • 2024年 4月 帝京科学大学 生命環境学部 アニマルサイエンス学科 学科長
  • 2022年 4月 帝京科学大学 生命環境学部 アニマルサイエンス学科 教授
  • 2019年 4月 帝京科学大学 生命環境学部 アニマルサイエンス学科 准教授
  • 2015年10月 岩手大学 農学部 共同獣医学科 准教授
  • 2014年 4月 農研機構 動物衛生研究所 上席研究員
  • 2008年 2月 米国農務省 南西部家禽研究所 訪問研究員(兼務)
  • 2003年10月 米国 トルードー研究所 訪問研究員(兼務)
  • 2001年 4月 農研機構 動物衛生研究所 主任研究員
  • 1992年 4月 農林水産省 家畜衛生試験場 研究員
主な著書
  • 動物看護用語辞典(分担執筆) EDUWARD Press 2025年4月
  • 家禽疾病学(分担執筆) 鶏病研究会 2021年3月
  • 家畜伝染病ハンドブック (分担執筆、共編者) 朝倉書店 2020年11月
  • 鳥の病気(分担執筆) 鶏病研究会 2014年
主な論文
  • Serum bta-miRNA-375 as a potential biomarker for the early diagnosis of enzootic bovine leukosis. Kenji Murakami, Towa Matsunaga, Takashi Matsuzaki, Yuta Naruke, Sonoko Miyauchi, Sota Kobayashi, Syuji Yoneyama, Yusuke Sakai, Toshihiro Ichijo, Toh-Ichi Hirata, Atsushi Kimura, Yuzumi Chiba, Kei-Ich Matsuda, Shinji Yamada, Hirokazu Hikono PLoS ONE 19(5) e0302868 2024年
  • Co-administration of a plasmid encoding CD40 or CD63 enhances the immune responses to a DNA vaccine against bovine viral diarrhea virus in mice.  Dongze Leng, Shinji Yamada, Yusuke Chiba, Syuji Yoneyama, Yusuke Sakai, Hirokazu Hikono, Kenji Murakami The Journal of veterinary medical science 2022年7月7日
  • Comparative Evaluation of Three Commercial Quantitative Real-Time PCRs Used in Japan for Bovine Leukemia Virus. Syuji Yoneyama, Sota Kobayashi, Towa Matsunaga, Kaoru Tonosaki, Dongze Leng, Yusuke Sakai, Shinji Yamada, Atsushi Kimura, Toshihiro Ichijo, Hirokazu Hikono, Kenji Murakami Viruses 14(6) 2022年5月28日
  • Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing Chihiro Ochiai, Sonoko Miyauchi, Yuta Kudo, Yuta Naruke, Syuji Yoneyama, Keisuke Tomita, Leng Dongze, Yusuke Chiba, To-ichi Hirata, Toshihiro Ichijo, Kazuya Nagai, Sota Kobayashi, Shinji Yamada, Hirokazu Hikono, Kenji Murakami PLOS ONE 16(9) e0256588-e0256588 2021年9月10日
  • Development of a microchip electrophoresis-based, high-throughput PCR-RFLP method to type Tax 233 variants of bovine leukemia virus in Japan Chihiro Ochiai, Yuzuru Katagiri, Sota Kobayashi, Ikunori Naitoh, Syuji Yoneyama, Keisuke Tomita, Leng Dongze, Hirokazu Hikono, Kenji Murakami
  •  Archives of Virology 165(12) 2961-2966 2020年12月
  • Development of a Multiplex PCR-Based Assay for Rapid Serotyping of Erysipelothrix Species. Yoshihiro Shimoji, Kazumasa Shiraiwa, Haruka Tominaga, Sayaka Nishikawa, Masahiro Eguchi,Hirokazu Hikono, Yohsuke Ogawa Journal of clinical microbiology 58(6) 2020年5月26日"
  • Nationwide Survey of Infectious Bronchitis Virus on Layer Farms in Japan During 2015. Masahiko Kaneda, Sayaka Takahashi, Ikunori Naito, Yusuke Chiba, Hirokazu Hikono, Kenji Murakami Avian diseases 64(1) 80-84 2020年3月
  • Recombinant Avian Paramyxovirus Serotypes 2, 6, and 10 as Vaccine Vectors for Highly Pathogenic Avian Influenza in Chickens with Antibodies Against Newcastle Disease Virus. Ryota Tsunekuni, Hirokazu Hikono, Taichiro Tanikawa, Riho Kurata, Takaaki Nakaya, Takehiko Saito Avian diseases 61(3) 296-306 2017年9月
  • Determination of O:4 antigen-antibody affinity level in O: 5 antigen positive and negative variants of Salmonella enterica serovar Typhimurium Yuka Nakai, Akihisa Ito, Yohsuke Ogawa, Swarmistha Devi Aribam, Marta Elsheimer-Matulova, Kazumasa Shiraiwa, Stevens M. B. Kisaka, Hirokazu Hikono, Sayaka Nishikawa, Masato Akiba, Kazuyoshi Kawahara, Yoshihiro Shimoji, Masahiro Eguchi FEMS MICROBIOLOGY LETTERS 364(7) 2017年4月
  • Susceptibility of chickens, quail, and pigeons to an H7N9 human influenza virus and subsequent egg-passaged strains Yuko Uchida, Katsushi Kanehira, Nobuhiro Takemae, Hirokazu Hikono, Takehiko Saito ARCHIVES OF VIROLOGY 162(1) 103-116 2017年1月
  • Initiation and regulation of immune responses to immunization with whole inactivated vaccines prepared from two genetically and antigenically distinct lineages of Egyptian influenza A virus subtype H5N1 Ahmed Samy, Mona I. El-Enbaawy, Ahmed A. El-Sanousi, Soad A. Nasef, Hirokazu Hikono, Takehiko Saito ARCHIVES OF VIROLOGY 161(10) 2797-2806 2016年10月
  • Nationwide Distribution of Bovine Influenza D Virus Infection in Japan Taisuke Horimoto, Takahiro Hiono, Hirohisa Mekata, Tomoha Odagiri, Zhihao Lei, Tomoya Kobayashi, Junzo Norimine, Yasuo Inoshima, Hirokazu Hikono, Kenji Murakami, Reiichiro Sato, Hironobu Murakami, Masahiro Sakaguchi, Kazunori Ishii, Takaaki Ando, Kounosuke Otomaru, Makoto Ozawa, Yoshihiro Sakoda, Shin Murakami PLOS ONE 11(9) e0163828 2016年9月
  • Cytokine responses to eye spray adjuvants for enhancing vaccine-induced immunity in chickens. Hiromi Takaki, Haruko Sato, Riho Kurata, Hirokazu Hikono, Takahiro Hiono, Hiroshi Kida, Misako Matsumoto, Takehiko Saito, Tsukasa Seya Microbiology and immunology 60(7) 511-5 2016年7月
  • Specific Monoclonal Antibody Overcomes the Salmonella enterica Serovar Typhimurium's Adaptive Mechanisms of Intramacrophage Survival and Replication Swarmistha Devi Aribam, Tomoyuki Harada, Marta Elsheimer-Matulova, Taketoshi Iwata, Katsushi Kanehira, Hirokazu Hikono, Hidenori Matsui, Yohsuke Ogawa, Yoshihiro Shimoji, Masahiro Eguchi PLOS ONE 11(3) e0151352 2016年3月
  • Different counteracting host immune responses to clade 2.2.1.1 and 2.2.1.2 Egyptian H5N1 highly pathogenic avian influenza viruses in naïve and vaccinated chickens. Samy AA, El-Enbaawy MI, El-Sanousi AA, Nasef SA, Naguib MM, Abdelwhab EM, Hikono H, Saito T Veterinary microbiology 183 103-109 2016年2月
  • Effect of semen extenders on frozen-thawed boar sperm characteristics and distribution in the female genital tract after deep intrauterine insemination in sows Michiko Noguchi, Koji Yoshioka, Hirokazu Hikono, Chie Suzuki, Kazuhiro Kikuchi ANIMAL REPRODUCTION SCIENCE 163 164-171 2015年12月
  • Variation in antigen-antibody affinity among serotypes of Salmonella O4 serogroup, determined using specific antisera Swarmistha Devi Aribam, Marta Elsheimer-Matulova, Hidenori Matsui, Jiro Hirota, Kazumasa Shiraiwa, Yohsuke Ogawa, Hirokazu Hikono, Yoshihiro Shimoji, Masahiro Eguchi FEMS MICROBIOLOGY LETTERS 362(21) 2015年11月
  • Development of an SNP-based PCR assay for rapid differentiation of a Japanese live vaccine strain from field isolates of Erysipelothrix rhusiopathiae Kazumasa Shiraiwa, Yohsuke Ogawa, Masahiro Eguchi, Hirokazu Hikono, Masahiro Kusumoto, Yoshihiro Shimoji JOURNAL OF MICROBIOLOGICAL METHODS 117 11-13 2015年10月
  • Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog Haruko Sato, Hiroyuki Oshiumi, Hiromi Takaki, Hirokazu Hikono, Tsukasa Seya MICROBIOLOGY AND IMMUNOLOGY 59(10) 633-640 2015年10月
  • Characterization of an H5N8 influenza A virus isolated from chickens during an outbreak of severe avian influenza in Japan in April 2014 Katsushi Kanehira, Yuko Uchida, Nobuhiro Takemae, Hirokazu Hikono, Ryota Tsunekuni, Takehiko Saito ARCHIVES OF VIROLOGY 160(7) 1629-1643 2015年7月
  • A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein Michinori Kakisaka, Yutaka Sasaki, Kazunori Yamada, Yasumitsu Kondoh, Hirokazu Hikono, Hiroyuki Osada, Kentaro Tomii, Takehiko Saito, Yoko Aida PLOS PATHOGENS 11(7) e1005062 2015年7月
  • Centrifugation on Percoll density gradient enhances motility, membrane integrity and in vitro fertilizing ability of frozen-thawed boar sperm Michiko Noguchi, Koji Yoshioka, Hirokazu Hikono, Gentaro Iwagami, Chie Suzuki, Kazuhiro Kikuchi ZYGOTE 23(1) 68-75 2015年2月
  • Evaluation of avian paramyxovirus serotypes 2 to 10 as vaccine vectors in chickens previously immunized against Newcastle disease virus Ryota Tsunekuni, Hirokazu Hikono, Takehiko Saito VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 160(3-4) 184-191 2014年8月
  • Identification of a novel multiple kinase inhibitor with potent antiviral activity against influenza virus by reducing viral polymerase activity Yutaka Sasaki, Michinori Kakisaka, Nopporn Chutiwitoonchai, Shigeru Tajima, Hirokazu Hikono, Takehiko Saito, Yoko Aida BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450(1) 49-54 2014年7月
  • Reassortant swine influenza viruses isolated in Japan contain genes from pandemic A(H1N1) 2009 Katsushi Kanehira, Nobuhiro Takemae, Yuko Uchida, Hirokazu Hikono, Takehiko Saito MICROBIOLOGY AND IMMUNOLOGY 58(6) 327-341 2014年6月
  • Intraocular vaccination with an inactivated highly pathogenic avian influenza virus induces protective antibody responses in chickens Hirokazu Hikono, Masaji Mase, Aya Matsuu, Megumi Nakayama, Takehiko Saito VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 151(1-2) 83-89 2013年1月
  • Genetics and infectivity of H5N1 highly pathogenic avian influenza viruses isolated from chickens and wild birds in Japan during 2010-11 Yuko Uchida, Yasushi Suzuki, Masayuki Shirakura, Akira Kawaguchi, Eri Nobusawa, Taichiro Tanikawa, Hirokazu Hikono, Nobuhiro Takemae, Masaji Mase, Katsushi Kanehira, Tsuyoshi Hayashi, Yuichi Tagawa, Masato Tashiro, Takehiko Saito VIRUS RESEARCH 170(1-2) 109-117 2012年12月
  • Induction of a cross-reactive antibody response to influenza virus M2 antigen in pigs by using a Sendai virus vector Hirokazu Hikono, Ayako Miyazaki, Masaji Mase, Makoto Inoue, Mamoru Hasegawa, Takehiko Saito VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 146(1) 92-96 2012年3月
  • Effect of perfluorooctane sulfonate (PFOS) on influenza A virus-induced mortality in female B6C3F1 mice Keerthi S. Guruge, Hirokazu Hikono, Nobuaki Shimada, Kenji Murakami, Jun Hasegawa, Leo W. Y. Yeung, Noriko Yamanaka, Nobuyoshi Yamashita JOURNAL OF TOXICOLOGICAL SCIENCES 34(6) 687-691 2009年12月
  • Oral vaccination against mycoplasmal pneumonia of swine using a live Erysipelothrix rhusiopathiae vaccine strain as a vector Yohsuke Ogawa, Eiji Oishi, Yoshihiro Muneta, Akiyuki Sano, Hirokazu Hikono, Tomoyuki Shibahara, Yukio Yagi, Yoshihiro Shimoji VACCINE 27(33) 4543-4550 2009年7月
  • Immune Response of Gnotobiotic Piglets against Mycoplasma hyopneumoniae Yoshihiro Muneta, Yu Minagawa, Yoshihiro Shimoji, Yohsuke Ogawa, Hirokazu Hikono, Yasuyuki Mori JOURNAL OF VETERINARY MEDICAL SCIENCE 70(10) 1065-1070 2008年10月
  • Activation phenotype, rather than central-or effector-memory phenotype, predicts the recall efficacy of memory CD8(+) T cells Hirokazu Hikono, Jacob E. Kohlmeier, Shiki Takamura, Susan T. Wittmer, Alan D. Roberts, David L. Woodland JOURNAL OF EXPERIMENTAL MEDICINE 204(7) 1625-1636 2007年7月
  • Anti-bovine CD34 monoclonal antibody reveals polymorphisms within coding region of the CD34 gene M Sakurai, T Furusawa, M Ikeda, H Hikono, S Shimizu, H Gotoh, E Kobayashi, E Momotani EXPERIMENTAL HEMATOLOGY 34(7) 905-913 2006年7月
  • T-cell memory and recall responses to respiratory virus infections H Hikono, JE Kohlmeier, KH Ely, Scott, I, AD Roberts, MA Blackman, DL Woodland IMMUNOLOGICAL REVIEWS 211 119-132 2006年6月
  • Neutralization of interleukin-10 significantly enhances gamma interferon expression in peripheral blood by stimulation with Johnin purified protein derivative and by infection with Mycobacterium avium subsp paratuberculosis in experimentally infected cattle with paratuberculosis JJ Buza, H Hikono, Y Mori, R Nagata, S Hirayama, AM Bari, Aodon-geril, YJ Shu, NM Tsuji, E Momotani INFECTION AND IMMUNITY 72(4) 2425-2428 2004年4月
  • Mycobacterium avium subsp paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle JJ Buza, Y Mori, AM Bari, H Hikono, Aodon-geril, S Hirayama, YJ Shu, E Momotani INFECTION AND IMMUNITY 71(12) 7223-7227 2003年12月
  • ephA9, a novel avian receptor tyrosine kinase gene E Sasaki, H Hikono, Y Kaku, T Kuwana, M Naito, M Sakurai GENE 316 103-110 2003年10月
  • Production of a monoclonal antibody that recognizes bovine stem cell factor (SCF) and its use in the detection and quantitation of native soluble bovine SCF in fetal bovine serum H Hikono, JH Zhou, M Ohta, S Inumaru, E Momotani, M Sakurai JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 22(2) 231-235 2002年2月
  • Cloning of bovine CD34 cDNA JH Zhou, H Hikono, M Ohta, M Sakurai JOURNAL OF VETERINARY MEDICAL SCIENCE 63(9) 1051-1053 2001年9月
  • Expression and distribution of the Kit receptor in bovine bone marrow cells H Hikono, M Ohta, JH Zhou, M Sakurai AMERICAN JOURNAL OF VETERINARY RESEARCH 62(6) 974-977 2001年6月
  • Expression of Kit, the receptor for stem cell factor, in bovine peripheral blood H Hikono, M Ohta, M Sakurai, E Momotani JOURNAL OF VETERINARY MEDICAL SCIENCE 63(3) 321-324 2001年3月Production and characterization of monoclonal antibodies that recognize bovine Kit receptor H Hikono, M Ohta, T Kubota, JH Zhou, S Inumaru, M Sakurai VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 68(2-4) 101-112 1999年5月
  • Ontogeny of inhibin secretion in the rat testis: secretion of inhibin-related proteins from fetal Leydig cells and of bioactive inhibin from Sertoli cells J Noguchi, H Hikono, S Sato, G Watanabe, K Taya, S Sasamoto, Y Hasegawa JOURNAL OF ENDOCRINOLOGY 155(1) 27-34 1997年10月
  • Cloning and characterization of cDNAs encoding two normal isoforms of bovine stem cell factor. Zhou JH, Hikono H, Ohtaki M, Kubota T, Sakurai M Biochimica et biophysica acta 1223(1) 148-150 1994年8月
  • SEQUENCE OF A BOVINE C-KIT PROTOONCOGENE CDNA T KUBOTA, H HIKONO, E SASAKI, M SAKURAI GENE 141(2) 305-306 1994年4月
所属学会等
  • 日本獣医学会
  • 動物用ワクチンバイオ医薬品研究会
その他の活動
  • 2025年4月 動物看護師統一認定機構 愛玩動物看護師試験委員
  • 2019年4月 日本動物看護学会誌 Veterinary Nursing 編集委員
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