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教員詳細

彦野　弘一 (ひこの　ひろかず)

彦野　弘一

役職：学科長・教授・博士（獣医学）

主な研究と活動

動物の健康を保ち、その生命を衛るために、動物の感染症にかかわる病原微生物とワクチンについて研究しています。ワンヘルス（One Health）の考え方をもとに、動物そのものだけではなく、動物と人、動物と環境の関係にも着目し、研究を進めていきます。動物保健衛生学研究室では、論文講読と卒業研究を通じて、病原微生物についての専門的な知識と取り扱いを身につけ、動物病院や検査・研究機関などのさまざまな動物関係職域において活躍できる人材の育成を目指しています。

キーワード 動物感染症、ワクチン
専門分野 獣医微生物学、獣医免疫学、獣医感染症学
主な研究対象

ウイルス、細菌、ウシ、ブタ、ニワトリ
担当科目 動物病原微生物学、動物感染症学、動物公衆衛生学、アニマルサイエンス実習
研究室番号 16-16
免許・資格
  • 獣医師免許
卒業年月
  • 1992年 3月　東京農工大学 農学部 獣医学科
学歴・経歴
  • 1992年 4月　農林水産省 家畜衛生試験場 研究員
  • 2001年 4月　農研機構動物衛生研究所 主任研究員
  • 2003年10月　Trudeau Institute 訪問研究員（兼任）
  • 2008年 2月　米国農務省　Southeast Poultry Research Laboratory　訪問研究員（兼任）
  • 2014年 4月　農研機構動物衛生研究所 インフルエンザ・プリオン病研究センター 上席研究員
  • 2015年10月　岩手大学 農学部 共同獣医学科 准教授
  • 2019年 4月　帝京科学大学 生命環境学部 アニマルサイエンス学科 准教授
主な著書
  • 彦野弘一：鶏の免疫学、家禽疾病学（鶏病研究会編）、26-29、鶏病研究会（2021）
  • 彦野弘一：兎出血病、兎粘液腫、家畜伝染病ハンドブック（村上賢二・彦野弘一編）、268-271、朝倉書店（2020）
主な論文
  • Tomita K, Miyauchi S, Katagiri Y, Yoneyama S, Dongze L, Chiba Y, Hirata TI, Ichijo T, Yasuda HA, Hikono H, Murakami K. Effectiveness of on-farm continuous flow high-temperature short-time pasteurization for inactivation of bovine leukemia virus in milk. Anim Sci J. 2020 Jan;91(1):e13495. doi: 10.1111/asj.13495.
  • Ochiai C, Katagiri Y, Kobayashi S, Naitoh I, Yoneyama S, Tomita K, Dongze L, Hikono H, Murakami K. Development of a microchip electrophoresis-based, high-throughput PCR-RFLP method to type Tax 233 variants of bovine leukemia virus in Japan. Arch Virol. 2020 Dec;165(12):2961-2966. doi: 10.1007/s00705-020-04842-w. Epub 2020 Oct 10.
  • Shimoji Y, Shiraiwa K, Tominaga H, Nishikawa S, Eguchi M, Hikono H, Ogawa Y. Development of a Multiplex PCR-Based Assay for Rapid Serotyping of Erysipelothrix Species. J Clin Microbiol. 2020 May 26;58(6):e00315-20. doi: 10.1128/JCM.00315-20.
  • Kaneda M, Takahashi S, Naito I, Chiba Y, Hikono H, Murakami K. Nationwide Survey of Infectious Bronchitis Virus on Layer Farms in Japan During 2015. Avian Dis. 2020 Mar;64(1):80-84. doi: 10.1637/0005-2086-64.1.80.
  • R, Hikono H, Tanikawa T, Kurata R, Nakaya T, Saito T. Recombinant Avian Paramyxovirus Serotypes 2, 6, and 10 as Vaccine Vectors for Highly Pathogenic Avian Influenza in Chickens with Antibodies Against Newcastle Disease Virus. Avian Dis. 2017 Sep;61(3):296-306. doi:10.1637/11512-100616-RegR1.
  • Samy A, El-Enbaawy MI, El-Sanousi AA, Nasef SA, Hikono H, Saito T. Initiation and regulation of immune responses to immunization with whole inactivated vaccines repared from two genetically and antigenically distinct lineages of Egyptian influenza A virus subtype H5N1. Arch Virol. 2016 Oct;161(10):2797-806.doi:10.1007/s00705-016-2989-2. Epub 2016 Jul 23.
  • Takaki H, Sato H, Kurata R, Hikono H, Hiono T, Kida H, Matsumoto M, Saito T, Seya T. Cytokine responses to eye spray adjuvants for enhancing vaccine-induced immunity in chickens. Microbiol Immunol. 2016 Jul;60(7):511-5. doi:10.1111/1348-0421.12391.
  • Uchida Y, Kanehira K, Takemae N, Hikono H, Saito T. Susceptibility of chickens, quail, and pigeons to an H7N9 human influenza virus and subsequent egg-passaged strains. Arch Virol. 2017 Jan;162(1):103-116. doi:10.1007/s00705-016-3090-6. Epub 2016 Sep 29.
  • Samy AA, El-Enbaawy MI, El-Sanousi AA, Nasef SA, Naguib MM, Abdelwhab EM, Hikono H, Saito T. Different counteracting host immune responses to clade 2.2.1.1 and 2.2.1.2 Egyptian H5N1 highly pathogenic avian influenza viruses in naïve and vaccinated chickens. Vet Microbiol. 2016 Feb 1;183:103-9.doi:10.1016/j.vetmic.2015.12.005. Epub 2015 Dec 12.
  • Sato H, Oshiumi H, Takaki H, Hikono H, Seya T. Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog. Microbiol Immunol.2015 Oct;59(10):633-40. doi: 10.1111/1348-0421.12322.
  • Kanehira K, Uchida Y, Takemae N, Hikono H, Tsunekuni R, Saito T. Characterization of an H5N8 influenza A virus isolated from chickens during an outbreak of severe avian influenza in Japan in April 2014. Arch Virol. 2015 Jul;160(7):1629-43. doi: 10.1007/s00705-015-2428-9. Epub 2015 Apr 24.
  • Tsunekuni R, Hikono H, Saito T. Evaluation of avian paramyxovirus serotypes 2 to 10 as vaccine vectors in chickens previously immunized against Newcastle disease virus. Vet Immunol Immunopathol. 2014 Aug 15;160(3-4):184-91.doi:10.1016/j.vetimm.2014.05.001. Epub 2014 May 14.
  • Kanehira K, Takemae N, Uchida Y, Hikono H, Saito T. Reassortant swine influenza viruses isolated in Japan contain genes from pandemic A(H1N1) 2009. Microbiol Immunol. 2014 Jun;58(6):327-41. doi: 10.1111/1348-0421.12152.
  • Hikono H, Mase M, Matsuu A, Nakayama M, Saito T. Intraocular vaccination with an inactivated highly pathogenic avian influenza virus induces protective antibody responses in chickens. Vet Immunol Immunopathol. 2013 Jan15;151(1-2):83-9. doi: 10.1016/j.vetimm.2012.10.005. Epub 2012 Nov 2.
  • Uchida Y, Suzuki Y, Shirakura M, Kawaguchi A, Nobusawa E, Tanikawa T, Hikono H, Takemae N, Mase M, Kanehira K, Hayashi T, Tagawa Y, Tashiro M, Saito T. Genetics and infectivity of H5N1 highly pathogenic avian influenza viruses isolated from chickens and wild birds in Japan during 2010-11. Virus Res. 2012 Dec;170(1-2):109-17. doi: 10.1016/j.virusres.2012.09.004. Epub 2012 Sep 19.
  • Hikono H, Miyazaki A, Mase M, Inoue M, Hasegawa M, Saito T. Induction of a cross-reactive antibody response to influenza virus M2 antigen in pigs by using a Sendai virus vector. Vet Immunol Immunopathol. 2012 Mar 15;146(1):92-6. doi:10.1016/j.vetimm.2012.01.017. Epub 2012 Jan 26.
  • Ogawa Y, Oishi E, Muneta Y, Sano A, Hikono H, Shibahara T, Yagi Y, Shimoji Y. Oral vaccination against mycoplasmal pneumonia of swine using a live Erysipelothrix rhusiopathiae vaccine strain as a vector. Vaccine. 2009 Jul 16;27(33):4543-50. doi: 10.1016/j.vaccine.2009.04.081. Epub 2009 May 21.
  • Muneta Y, Minagawa Y, Shimoji Y, Ogawa Y, Hikono H, Mori Y. Immune response of gnotobiotic piglets against Mycoplasma hyopneumoniae. J Vet Med Sci. 2008 Oct;70(10):1065-70.
  • Hikono H, Kohlmeier JE, Takamura S, Wittmer ST, Roberts AD, Woodland DL.Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. J Exp Med. 2007 Jul 9;204(7):1625-36.Epub 2007 Jul 2.
  • Hikono H, Kohlmeier JE, Ely KH, Scott I, Roberts AD, Blackman MA,Woodland DL. T-cell memory and recall responses to respiratory virus infections. Immunol Rev. 2006 Jun;211:119-32.
  • Buza JJ, Hikono H, Mori Y, Nagata R, Hirayama S, Aodon-geril, Bari AM, Shu Y,Tsuji NM, Momotani E. Neutralization of interleukin-10 significantly enhances gamma interferon expression in peripheral blood by stimulation with Johnin purified protein derivative and by infection with Mycobacterium avium subsp. paratuberculosis in experimentally infected cattle with paratuberculosis. Infect Immun. 2004 Apr;72(4):2425-8.
  • Buza JJ, Mori Y, Bari AM, Hikono H, Aodon-geril, Hirayama S, Shu Y, Momotani E. Mycobacterium avium subsp. paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle. Infect Immun. 2003 Dec;71(12):7223-7.
  • Hikono H, Zhou JH, Ohta M, Inumaru S, Momotani E, Sakurai M. Production of a monoclonal antibody that recognizes bovine stem cell factor (SCF) and its use in the detection and quantitation of native soluble bovine SCF in fetal bovine serum. J Interferon Cytokine Res. 2002 Feb;22(2):231-5.
  • Zhou JH, Hikono H, Ohta M, Sakurai M. Cloning of bovine CD34 cDNA. J Vet Med Sci. 2001 Sep;63(9):1051-3.
  • Hikono H, Ohta M, Zhou JH, Sakurai M. Expression and distribution of the Kit receptor in bovine bone marrow cells. Am J Vet Res. 2001 Jun;62(6):974-7.
  • Hikono H, Ohta M, Sakurai M, Momotani E. Expression of Kit, the receptor for stem cell factor, in bovine peripheral blood. J Vet Med Sci. 2001 Mar;63(3):321-4.
  • Kubota T, Hikono H, Sasaki E, Sakurai M. Sequence of a bovine c-kit proto-oncogene cDNA. Gene. 1994 Apr 20;141(2):305-6.
  • Zhou JH, Hikono H, Ohtaki M, Kubota T, Sakurai M. Cloning and characterization of cDNAs encoding two normal isoforms of bovine stem cell factor. Biochim Biophys Acta. 1994 Aug 11;1223(1):148-50.
  • Hikono H, Ohta M, Kubota T, Zhou JH, Inumaru S, Sakurai M. Production and characterization of monoclonal antibodies that recognize bovine Kit receptor. Vet Immunol Immunopathol. 1999 May;68(2-4):101-12.
所属学会等
  • 日本獣医学会
  • 日本ウイルス学会
  • 日本細菌学会
  • 日本免疫学会
  • 動物用ワクチン・バイオ医薬品研究会
  • 米国免疫学会
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