主な論文 |
- Saito M, Ishida N, Yamada H, Ibi M, Hirose M*. 8-HEPE-concentrated materials from Pacific krill improve plasma cholesterol levels and hepatic steatosis in high cholesterol diet-fed low-density lipoprotein (LDL) receptor-deficient mice. Biol Pharm Bull. 2020 in press.
- Yamada H*., Kumagai K., Uemura A. and Yuki S. Euphausia pacifica as a source of 8(R)-hydroxy-eicosapentaenoic acid (8R-HEPE), 8(R)-hydroxy-eicosatetraenoic acid (8R-HETE) and 10(R)-hydroxy-docosahexaenoic acid (10R-HDHA). Bioscience, Biotechnology, and Biochemistry. 84: 455-462 (2020)
- Yamada H. *, Hakozaki M., Uemura A., and Yamashita T. Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells. Journal of Lipid Research. 60: 1491-1502 (2019)
- Uchida T., Koshino H., Abe J., Hakozaki M., Yamada H., and Kimura KI*. Isolation of yeast Ca2+ signal transduction inhibitors from the Early Cretaceous Burmese amber. Fitoterapia. 34: 422-428 (2019)
- Yamada H.*, Hakozaki M., Shiraishi A., Kumagai K., Ido A. and Tsurumi K. Changes in lipids during the ovary maturation process of Balanus rostratus. Zoological Science. 36: 182-188 (2019)
- Takahashi H.*, Kikuchi-Fujisaki S., Yoshida C., Yamada H., Yamashita T., Konno N., and Takeda T. Gtgen3A, a novel plant GH3 β-glucosidase, modulates gentio-oligosaccharide metabolism in Gentiana. Biochem. J. 475: 1309-1322 (2018)
- Nagahora N.*, Yamada H., Kikuchi S., Hakozaki M. and Yano A. Nrf2 Activation by 5-lipoxygenase Metabolites in Human Umbilical Vascular Endothelial Cells. Nutrients. 9: 1001 (2017)
- Hosogane M., Bosu L., Fukumoto E., Yamada H., Sato S., and Nakayama K. Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells. Genes Cells. 22: 360-375 (2017)
- Yamada H.*, Yamazaki Y., Koike S., Hakozaki M., Nagahora N., Yuki S., Yano A., Tsurumi K., and Okumura T. Lipids, fatty acids and hydroxyfatty acids of Euphausia pacifica. Scientific Reports. 7: 9944 (2017)
- Yamada H.*, Kikuchi S., Hakozaki M. Motodate K., Nagahora N. and Hirose M. 8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice. Journal of Lipids. 7498508 (2016)
- Yamada H.*, Kikuchi S., Inui T., Takahashi H., and Kimura KI. Gentiolactone, a secoiridoid dilactone from Gentiana triflora, inhibits TNF-a, iNOS and Cox-2 mRNA expression and blocks NF-κB promoter activity in murine macrophages. PLoS ONE. 9: e113834 (2014)
- Yamada H.*, Oshiro E., Kikuchi S., Hakozaki M., Takahashi H., and Kimura KI. Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs. Journal of Lipid Research. 55: 895-904 (2014)
- Yano A.*, Abe A., Aizewa F., Yamada H., Minami K., Matsui M., and Kishi M. The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home. Mar. Drugs. 11: 4993-5007 (2013)
- Takahashi H.*, Yamada H., Yoshida C., and Imamura T. Modification of light quality improves the growth and medicinal quality of clonal plantlets derived from the herbal plant Gentiana. Plant Biotechnology. 29: 1-4 (2012)
- Sadzuka Y.*, Sugiyama I., Miyashita M., Ueda T., Kikuchi S., Oshiro E., Yano A., and Yamada H. Beneficial effects by intake of Euphausiacea pacifica on high-fat diet-induced obesity. Biol. Pharm. Bull. 35: 568-572 (2012)
- Yamada H.*, Ueda T., and Yano A. Water-Soluble Extract of Pacific Krill Prevents Triglyceride Accumulation in Adipocytes by Suppressing PPARγ and C/EBPα Expression. PLoS ONE. 6: e21952 (2011)
- Inoue T., Nakayama Y., Yamada H., Li YC., Yamaguchi S., Osaki M., Kurimasa A., Hiratsuka M., Katoh M., and Oshimura M*. SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest. Cell Cycle. 8:1 279-91 (2009)
- Yamada H., Li YC., Nishikawa M., Oshimura M., and Inoue T*. Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion. Journal of Human Genetics. 53: 447-53 (2008)
- Inoue T., Hiratsuka M., Osaki M., Yamada H., Kishimoto I., Yamaguchi S., Nakano S., Katoh M., Ito H., and Oshimura M*. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene. 26: 945-57 (2007)
- Kawahara M., Inoue T., Ren X., Sogo T., Yamada H., Katoh M., Ueda H., Oshimura M., and Nagamune T*. Antigen-mediated growth control of hybridoma cells via a human artificial chromosome. Biochim Biophys Acta. 1770: 206-12 (2007)
- Yamada H., Kunisato A., Kawahara M., Tahimic CG., Ren X., Ueda H., Nagamune T., Katoh M., Inoue T., Nishikawa M., and Oshimura M*. Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome. Journal of Human Genetics. 51: 147-50 (2006)
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学会発表(国際学会) |
- 発表者:○Yamada H, Hakozaki M, Uemura A, Yamashita T. 題名:The mechanisms of anti-melanogenesis and anti-tumor effects of EPA and DHA 学会名:59th International Conference on the Bioscience of Lipids (ICBL) Abstract Number: 55 場所:Helsinki, Finland. 4 - 7 September, 2018.
- 発表者:○Yamada H, Hakozaki M, Motodate K, Nagahora N, Hirose M 題名:8-Hydroxyeicosapentaenoic acid (8-HEPE) decreases plasma and hepatic triglycerides in high fat diet-induced obese mice 学会名:International Society for the Study of Fatty Acids and Lipids (ISSFAL 2016) Abstract Number: 109 場所:Stellenbosch univercity, South Africa. 5 - 9 September, 2016.
- 発表者:○Yamada H, Oshiro E, Kikuchi S, Hakozaki M, Takahashi H, Kimura KI. 題名:Hydroxylation of eicosapentaeic acid at the C-8 or C-9 position increases ligand activity for PPARs. 学会名:International Society for the Study of Fatty Acids and Lipids (ISSFAL 2014) Abstract Number: M1.01. 場所:Stockholm, Sweeden . June 28 – July 3, 2014
- 発表者:○Yamada H, Kunisato A, Nishikawa M, Oshimura M 題名:A model for gene-modified cell therapies: Exogenous gene expression and growth regulation of hematopoietic cells via human artificial chromosomes.
- 学会名:International Society for Stem Cell Research 3rd Annual Meeting Abstract Number: 616. 場所:San Francisco, California USA. June 23-25, 2005
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